| Year | Single | Peak chart positions | Album |
|---|
US
[25] | US Alt
[26] | US AC
[27] | US AAA
[28] | AUS
[2] | FRA
[3] | GER
[29] | NL
[5] | NZ
[6] | SWE
[8] | UK
[9] |
|---|
| 1985 | "Dancin'" | — | — | — | — | 46 | — | — | — | — | — | — | Silvertone |
| "Gone Ridin'" | — | — | — | — | — | — | — | — | — | — | — |
| 1986 | "Livin' for Your Lover" | — | — | — | — | — | — | — | 50 | — | — | — |
| 1987 | "You Owe Me Some Kind of Love" | — | — | — | — | — | — | — | — | — | — | — | Chris Isaak |
| "Blue Hotel" | — | — | — | — | — | 28 | — | 42 | — | — | 100 |
| "Lie to Me" | — | — | — | — | — | — | — | 48 | — | — | — |
| "Heart Full of Soul" | — | — | — | — | — | — | — | — | — | — | — |
| 1989 | "Don't Make Me Dream About You" | — | 18 | — | — | — | — | — | — | — | — | — | Heart Shaped World |
| 1990 | "Wicked Game" | 6 | 2 | 12 | — | 15 | 42 | 9 | 5 | 7 | 3 | 10 |
|